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Holmes may refer to:
- Seagrave Holmes, a merchant and resident of Rivet City in Fallout 3.
- Annette Holmes, the grandmother of Seagrave Holmes mentioned in Fallout 3.
- Malcolm Holmes, a trader living in the Mojave Wasteland in Fallout: New Vegas.
- SSHQMalcolmHolmes.txt, dialogue for Malcolm Holmes in Fallout: New Vegas.