As with all houses in Tranquility Lane, it has 2 stories with the front door entering into the lounge, which in addition to the normal lounge furniture items, features a chandelier, Radiation King radio and robotic assistance in the form of a Mister Handy. The other ground level rooms are a kitchen, which contains a terminal, and a bathroom. Upstairs, the house has another bathroom, and a bedroom with 2 single beds. At the top of the stairs, there is a roller skate found on the floor.
The Henderson residence contains a number of special items that can be interacted with to complete Betty's tasks, namely the chandelier, roller skate, oven, computer terminal and Mister Handy.
When first entering this residence the Lone Wanderer can detect a "radio signal" which is unnamed and cannot be received, due that the her/she can't access their Pip-Boy 3000. This is likely because there is a radio in here which can be turned on. Only static will be heard, though.
If one uses console commands to noclip under the house, there's a terminal underneath it. The Lone Wanderer can talk to it, and it responds with "yeah" and "later".