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The Smiths and Wilsons would prefer you took no notice of this eldery kook, who lives in his rundown shack. He's obviously a lunatic, and reeks of cheap alcohol.[1]
Harris is a former cannibal and is part of the unmarked quest Our Little Secret. He asks you to leave and save yourself, stating things in Andale are not what they seem to be.
If the player discovers the secret of the town, by going into either the Wilsons' shed or the Smiths' basement and subsequently kills the residents, Old Man Harris will become the guardian of the children and speak more openly of his history. He is the one who tells you about the cannibalism, but the others tell you he went mad ever since his wife died.
He is the father of both Linda Smith and Martha Wilson; you can learn this by passing some speech checks.
If you kill Jenny and Junior's parents, they will come to live with Old Man Harris. If you kill Old Man Harris after this, the children do not seem to care or notice, even if you do it right in front of them.
Killing Old Man Harris will not incur a penalty to Karma.
Even after you kill Junior and Jenny's parents, Old Man Harris will continue to say things like "Don't be fooled by them!" during dialog.
"No! Well... yes. But it's all a trick. Don't you know anything? Does that number on your back mean that you just crawled out of a vault or something?" (When wearing a Vault jumpsuit)