Jeremiah Rigdon had a vision in which God commanded him to wipe Jericho off the face of the earth so that the Mormons can rise again. The Mormons regrouped, and the Hands of God began raiding Jericho's water caravans, weakening the town in preparation for the day of reckoning.
Hands of God have not appeared nor are they mentioned in any published game. They were to appear only in Van Buren, the canceled Fallout 3 by Black Isle Studios. It is not certain if they will appear in any future Fallout game.