Grandma was a citizen-puppet of Vault 77 in Penny Arcade's One Man, and a Crate of Puppets comic.
She is an old granny puppet found in the puppet crate in Vault 77. She is a 'friend' of the Vault 77 Dweller and once made him pies. She was also a witness of The King puppet's death.
Grandma appears only in One Man, and a Crate of Puppets.