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Grandma may refer to:
- Grandma, a citizen-puppet of Vault 77 in Penny Arcade's One Man, and a Crate of Puppets comic.
- Grandma Sparkle, a trader and cook at Wilhelm's Wharf in Fallout 3.
- Grandma Taylor, a resident of Vault 101 in Fallout 3.
- Lily Bowen, a nightkin and possible companion living in Jacobstown in Fallout: New Vegas.