The Goodsprings settlers are mainly farmers, who specialize in working with brahmin and bighorners. They will greet the Courier with "Howdy.", "That doc' Mitchell sure knows his stuff, doesn't he? and "Way too many strangers coming into town these days... no offense."
Other than the named Goodsprings inhabitants, there are a total of 4 Goodsprings settlers living in the town. One lives in the house immediately west of Chet's shop, two live in the house in the middle of the town near Victor's shack and the schoolhouse (one works in the fields outside the house, while the other spends all his time either sleeping inside or drinking at Trudy's bar), and one final settler can be rescued from geckos at the end of the tutorial quest Back in the Saddle, at which point she will live inside Sunny Smiles' house.