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General store may refer to:
- Darkwaters General Store, a shop in Junktown run by Killian Darkwater in Fallout.
- All-n-One Store, a store run by Mitch in the Hub Downtown in Fallout.
- General store (Broken Hills), a store in Broken Hills run by Liz.
- Goodsprings General Store, a store run by Chet in Goodsprings in Fallout: New Vegas.
- Nipton General Store, a building in Nipton occupied by Boxcars in Fallout: New Vegas.
- Zion General Store, a location in Zion Canyon in the Fallout: New Vegas add-on Honest Hearts.