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General store may refer to:
- General store (Honest Hearts), a store in the Fallout: New Vegas add-on Honest Hearts
- Darkwaters General Store, store run by Killian Darkwater in Junktown in Fallout
- All-n-One Store, store run by Mitch in the Hub Downtown in Fallout
- Goodsprings General Store, a store run by Chet in Fallout: New Vegas
- Nipton General Store, a store in Nipton occupied by Powder Ganger Boxcars in Fallout: New Vegas, also called the Nipton Trading Post.