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Francis may refer to:
- Sister Francis, a member of the Children of the Cathedral in Fallout.
- Francis (Fallout 2), a Broken Hills super mutant in Fallout 2.
- Francis Lipsett, soldier who fought, and died, during the First Battle of Hoover Dam, mentioned in Fallout: New Vegas.
- Francis (Project V13), a Brotherhood of Steel Elder mentioned in The Armageddon Rag, Vol. 3.