Automated turrets are automatic, unmanned machine guns which are capable of sensing and attacking targets that are hostile to the faction or organization to which they belong. They are employed by both military organizations like the Enclave or Brotherhood of Steel and civilian operations such as the Museum of History, though in the latter case their former operators have been long since gone.

The MP-47/A Prototype Medic Power Armor was designed to administer medical attention to the user as necessary during combat.

Unfortunately, the prototype version can only administer Med-X, the game's version of morphine. Its outward appearance is nearly identical to T-4x power armor series.

The armor was planned as an automatic medical supply dispenser, meaning troops would not have to be evacuated for medical treatment. The user manual found with the armor details that the final version was to also include a lethal chemical that could be triggered by a superior officer if the soldier deserted.

General Constantine Chase was a pre-War U.S. Army General who commanded the United States troops during the Anchorage Reclamation in Alaska. He was responsible for commissioning the Liberty Prime project and the Anchorage Reclamation simulation. It is assumed that Fort Constantine is named after him. During the Tranquility Lane quest, the notes on the Chinese Invasion Simulation suggest that it was programmed by Chase's people at the request of Dr. Braun.

Vault 92 was one of the vaults created by Vault-Tec, and part of the Vault Experiment. The world's best musicians were invited to this vault to "preserve artistic talent" during the War. Vault 92's true purpose, however, was an experimental study in the creation of super soldiers. By exposing the citizens of the vault to white noise, the Vault Overseer and the vault doctor induced a trance-like state. While in the trance, the citizens became susceptible to mind control and were thus manipulated for research.

Frank Horrigan is the Enclave's finest instrument of warfare. Originally a Secret Service Agent for the President of the Enclave, Frank is sent out with several other teams to search for slaves to use for excavating the remains of Mariposa in 2236, sometime between July and August. In September, scientists unearth the F.E.V. virus and mutations begin to occur amongst those who come in contact with it. Horrigan is one of these unfortunate souls. He is quickly shuttled back to the Enclave for further research. The timeline is unknown, but between 2236 and 2238 Frank Horrigan undergoes his transformation into a super mutant. He is kept under heavy sedation and is operated on by Enclave technicians. In January of 2239, tests start to show negative results. It is then decided that Frank should be activated for field operations.

Liberty Prime is a U.S. Army pacification robot, originally designed to aid American troops in the liberation of Alaska from communist China. Yet another project commissioned by General Chase, it was not completed on schedule and America was forced to fight a long bloody battle using their other secret weapon, the more successful and reasonably-scaled power armor. Upon their arrival in the Capital Wasteland, the Brotherhood of Steel discover the non-functional giant in the ruins of the former Pentagon. It is this discovery that earns Owyn Lyons a promotion to Elder and spurs the construction of a permanent Brotherhood base in the ruins of Washington, D.C., later to be known as the Citadel.

Fort Bannister is a pre-war military installation north of Evergreen Mills. When the Great War came in 2077, it was one of the highest profile targets in the area, suffering a number of direct nuclear hits, which obliterated much of its surface facilities, leaving a gaping crater and concrete ruins behind. The nuclear detonation did not destroy the bunker's underground installations, however, which was likely the main reason it was secured by Talon Company mercenaries and used as their primary base.

Living in the Boneyard just to the north of Adytum in a pre-War nightclub, the Blades are a group of survivalists lead by a beautiful woman who goes by the name of Razor. While a peaceful group, overall, they are persecuted by the Regulators, who both coerce them into doing their bidding and frame them for crimes against the people of Adytum. Their intent is to make the town appear to be seriously threatened by the Blades as an excuse for the Regulators own repressive policies there.

Protector Henry Casdin is the leader of the Brotherhood of Steel Outcasts in the Capital Wasteland. According to Elder Owyn Lyons, he was one of the best fighters in the Brotherhood of Steel before he took other Brotherhood members and formed the Outcasts in order to continue the original mission. He trades the Lone Wanderer for technology that is acquired across the Wasteland and in return gives out useful supplies that the Outcasts' possess in abundance (see The Outcast Collection Agent).

Seymour is an unusual, intelligent, talking spore plant living in Broken Hills. He was grown from a tiny spore and nurtured by the insane Professor, but he realized from an early age that if he were to act as smart as he truly is, the professor would cut him into pieces to examine him. Therefore, Seymour played dumb and got planted outside.

The Oasis is a place somewhere in the Capital Wasteland that is unusually full of trees and other green plants. Harold, a special product of the forced evolutionary virus, with a tree on his head which he called Bob, found himself overwhelmed by it and became rooted to the ground during his travels in the Capital Wasteland. Here he was discovered by several people who began to worship him as a god, and a small and exclusive cult known as the Treeminders began to form in secrecy. Bob began to blossom (which Harold apparently finds embarrassing) and many plants grew in this area, which became green with life, a stark contrast to the outer wasteland.

Joanne Lynette is the First Citizen of Vault City in 2241. Lynette has an extreme managerial, economic, and efficient soul, and she's used to getting her way. She wasn't abused, tortured, or twisted in any way when she was young, she just got a certain privileged and superiority complex hardwired into her head around five or six years old, and she's never been the same. She's always known that she was destined to lead the Vault 8 citizens, and that power has gone to her head. She's been the leader of Vault City for many, many years, and she's seen the worst that the wasteland has to offer - but rather than taking sympathy on the poor souls that have come to Vault City for protection, she has instead taken the view that these "outlanders" were simply not strong or smart enough to achieve what Vault City has, and thus, are inferior. She tends to work too much and too hard, and she sees all her time as precious, so she has little patience for socializing without a purpose or for people dropping in and wasting her time.

Andale is a town in the south of the Capital Wasteland, touted by its residents as the greatest place on Earth. However, it seems that its purportedly inbred population harbors a dark secret. The town's name is a corrupted version of its pre-War name, Annandale, Virginia. Two of the host families, the Smiths and the Wilsons, seem to think it's still the pre-War era, while the third house is home to Old Man Harris, who warns you that they're stone cold killers and that you should run while you still have the chance.

The Pancor Jackhammer, despite its name, is an easy to control shotgun, even when fired on full automatic. The popular bullpup design, which places the magazine behind the trigger, makes the weapon well balanced & easy to control. In real life, the Jackhammer was a prototype design that failed to reach full-fledged production due to its manufacturer's bankruptcy. The game stays true to the weapon's reputation of control-ability, even with automatic fire.

Paladin Hoss is a member of the Brotherhood of Steel. During a training exercise in Falls Church, Knight Church, Paladin Hoss, Initiate Pek, and an unnamed Paladin were separated by a super mutant attack. Knight Church was killed in the initial attack and Initiate Pek became trapped in an office building while Paladin Hoss and the other Paladin were fighting nearby.

Big Guns is a Fallout, Fallout 2, Fallout Tactics, and Fallout 3 skill, that determines your combat effectiveness with over-sized weapons. The strength requirements of most big guns, combined with the weight of the guns themselves and the large amounts of ammo they require make investing into Strength points at character creation a prudent choice for players planning to use these weapons as their mainstays.

Lost Hills in Southern California is the headquarters of the Brotherhood of Steel, located northwest of Junktown and the Hub, southeast of the Mariposa Military Base and south of Vault 13. Lost Hills was a pre-war government security bunker. Located almost entirely underground, the only indication of the presence of this installation was a small, reinforced structure containing the primary access elevator. After the Brotherhood seized the location, two sentries in powered armour stood guard at the entrance at all times.

Psycho is a drug composed of strange and unknown chemicals of military origin, with a unique delivery system. It was designed at the orders of General Constantine Chase and is supposed to increase the combat potential of a soldier. Psycho appears to be a form of injected drug, which, considering the large serum canister next to the needle, suggests that large quantities are needed to produce the effects. Apparently the evidence of the needle and two additional canisters attached by wire to the hypodermic needle, seems to give evidence that psycho's chemicals must be mixed instantly and in large amounts before the injection into the body, otherwise the drug is worthless.

The Lieutenant or Lou, also lovingly dubbed Lou Tenant by some of his subordinates, is the Master's right hand and the overseer of all work inside Mariposa Military Base. Lou is a good example of how the Master would want his mutants to turn out: stronger, more intelligent, and overall superior to normal humans. His authority apparently stretches so far that Harry goes through the trouble of dragging you on a long journey through the Wasteland just to show you to the Lou and report you're not a ghoul. He appears to be a rather sadistic character who thoroughly enjoys torturing the Vault Dweller, as well as arrogantly self-assured concerning the superiority of Super Mutants over normal humans and ghouls, referring to the former as the "next step in human evolution".

The Calculator is the computer which controls Vault 0. Unlike the ZAX computers, it is not a real artificial intelligence, but rather a cyborg, because it is connected with several human brains.

The neural network is meant to assist in Vault 0's primary function: to initiate mankind's post-war rebirth. When outside temperature, radiation levels, and poison particle counts returned to acceptable levels, Vault 0 was to remotely activate the Exodus protocol, which would initialize the integration of all vault dwellers onto the planet's surface. However, it was only a plan that never came true.

The Calculator became corrupted due to fatal errors in his CPU and his data storage systems - human brains. The cybernetic machine becomes a mad personality, whose goals, while formulated as they are originally intended, now turn to a rather homicidal side.

The Outcast outpost is an Outcast camp which has been set up in the remains of the VSS Facility, a pre-War compound of Virtual Strategic Solutions, Inc. Part of the Operation: Anchorage add-on, it can be reached by elevator from Bailey's Crossroads. It houses the VSS Armory, an initially locked weapon cache filled with pre-War equipment, accessible only by completing the Anchorage Reclamation simulation in the building. It seems to have been left untouched since the bombs fell, or even about a year earlier, 2076, according to computer and development records recovered at the site.

Raiders are any group of people who pillage, plunder, murder, or otherwise ruin the day of anyone unfortunate enough to not be one of them. If there were still laws, they'd be outlaws. Raiders tend to organize into loose confederations of gangs in the post-apocalyptic wasteland and are a constant problem, because it's much easier for them to just shoot people for their money, food, and other valuables than to earn a living. They typically prey upon travelers and very small towns, leaving more populous areas alone, where they are outnumbered and have no element of surprise.

The CRB-S or Cerberus is a giant robot dog, quite a bit bigger than its smaller cyberdog cousins. Three specimen of this type of artificial organism can be encountered in Dog Town. One of Dog Town's quests is to get rid of these three robots, as they would continue to attack you until you did, although it was also possible to reprogram them to kill all the dogs that had spread through Denver.

As its name suggests, the deathclaw gauntlet is a craftable Unarmed weapon that is made out of a deathclaw's forearm, fist, and claws, a medical brace for extra structure, a leather belt to render the hand rigid (and as a handle for the user's hand), and wonderGlue to hold it all together.

General Jingwei was a pre-War Chinese Army General who commanded the Chinese troops during the Invasion of Alaska. Given that his shocksword was acquired by the U.S. Army, he likely died during the Anchorage Reclamation. Jingwei is a character in the Anchorage Reclamation simulation, and will be encountered in the simulation's climax. There he will be seen calmly executing an American captive with his shock sword in the midst of a battle between American and Chinese soldiers. After this he can be dealt with through either a Speech check or through combat.

Ronald Lee Ermey (born March 24, 1944) is a former U.S. Marine Corps drill instructor and later Golden Globe-nominated actor, often playing the roles of authority figures, such as Gunnery Sergeant Hartmann in Full Metal Jacket, Mayor Tilman in the Alan Parker film Mississippi Burning and Sheriff Hoyt in The Texas Chainsaw Massacre remake. In Fallout Tactics, he voiced General Simon Barnaky. One of his lines from the ninety minute pilot episode for Space Above and Beyond was referenced in Fallout 2 by Dornan.

The Van Buren version of the SPECIAL system, made by J.E. Sawyer, was highly modified in comparison to the previous Fallout games. Some of the changes, especially to the skills system, were quite controversial among Fallout fans. Bethesda's version of SPECIAL in Fallout 3 is a combination of the original SPECIAL, the Van Buren SPECIAL, as well as their own changes.

Set is the leader of all the ghouls in Necropolis in 2161, except for the underground ghouls who lived in the sewers and the Glowing ones who live in Vault 12. He has a son called Typhon. Set is annoyed at the super mutant presence in Necropolis and tries to recruit the Vault Dweller to take care of the problem. He is not mentioned in the Vault Dweller's memoirs, but the Vault Dweller did kill the super mutants, which led to the slaughter of everyone in Necropolis, including Set himself.

Skynet, Artificial Intelligence project number 59234, is a computer who manages the Sierra Army Depot. It does not entirely control the security systems directly, however, presumably to prevent sabatoge-prone overcentralization.

According to himself, Skynet, a new thinking computer, was conceived and developed in the year 2050 through the use of alien technology. In the year 2081, 4 years after the Great War, Skynet became self-aware. In 2120 Skynet was given a new set of instructions and then abandoned by its makers.

Skynet is bored with administering the depot by 2241, it having been 164 years since there was any real activity on base. It seeks to travel and learn about the world.