Icon disambig
For the condition that lists mutations, see mutations.
Each Disease has unique penalties. Use Disease Cures, Antibiotics, or wait until the Disease expires on its own.— In-game notification

Diseases are a type of condition in Fallout 76.

When the player character consumes unclean food and liquid, there is a chance of acquiring a disease. Being attacked by diseased creatures and sleeping on floor mattresses can also cause disease. Eating uncooked meat and drinking dirty water has the highest risks for disease. Diseases can be avoided by cooking food, eating pre-War packaged food and drinking boiled or purified water. Sleeping on raised mattresses and avoiding physical contact with diseased creatures will also avoid disease.

Diseases cause a variety of effects including increased damage and needs. Diseases are self-limiting and will expire. They can be cured with disease cures or antibiotics.

Maintaining a character's food and water needs increases resistance of disease by 25%, even more with the perk Rejuvenated. Taking RadAway also temporarily increases disease resistance. The perks Iron Stomach and Thirst Quencher greatly reduce the chance of disease from consumed food and liquid, respectively, while the perk Vaccinated protects against diseased creatures.

Intentionally catching diseases will be useful with the Plague Walker mutation, in which case the player should reference the consumables and regions lists to become familiar with the best methods of quickly accumulating diseases.


A character can get infected by these diseases:

Disease Effect(s) Duration Base ID Cause
The Blight -1 to all S.P.E.C.I.A.L stats 30 min ???????? Caught from a diseased Scorchbeast
Blood worms Take 25% more damage 15 min ????????
Bone worms Take 50% more limb damage 15 min ???????? Step on a punji board.
Buzz brain INT -2 60 min ???????? Attacked by a glowing ant
Dysentery Periodic water loss 15 min ???????? Eat raw carrots, spoiled meat, swim in toxic water
Fever claw -25% Damage with Ranged Weapons 15 min ????????
Flap limb STR -2 60 min ????????
Glowing pustules Bleed radiation from wounds 15 min ???????? Inflicted by a infected bloated glowing one.
Heat flashes END -2 45 min ????????
Jelly fingers +50% Ranged VATS AP Cost 15 min ????????
Lock joint Melee AP cost +50% 15 min ????????
Needle spine -10 Carry Capacity 15 min ???????? Caught from a diseased angler.
Parasites Periodic food loss 15 min ???????? Caught from a diseased tick, swimming in water, eating raw mutfruit, drinking cream.
Rad worms Take 50% more radiation damage. 15 min ???????? Inflicted by a diseased feral ghoul stalker.
Rattle hands -25% damage with ranged weapons 45 min ????????
Shell shock Action Point drain from wounds 45 min ????????
Sludge lung Max AP -50, AP regen -50 60 min ???????? Breathe the air near Belching Betty
Snot ear PER -2 15 min ???????? Inflicted by a diseased snallygaster
Swamp gas CHR -2 15 min ???????? Inflicted by a diseased bloatfly
Swamp itch AGI -2 15 min ???????? Sleep in a sleeping bag/mattress on the ground.
Waterborne ????????
Weeping sores Bleed from wounds 45 min ????????
Woopsies LCK -2 15 min ???????? Inflicted by a scorched ant during the scorchbeast queen encounter