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Colonel Hollis was previously in charge of a squad of Minutemen, left without higher leadership or a base of operations after the death of General McGann and the mirelurk invasion of The Castle. When he received word of an impending attack on Quincy, he and his men went to defend them, arriving in time to push back a group of Gunners. Fearing further attack, Hollis sent out for reinforcements, but his call was never answered due to political infighting within the Minutemen. Sickened by this, one of Hollis's squad, Clint, abandoned them and joined the Gunners. With Clint's help, the Gunners launched a second attack and successfully destroyed the town, killing many including Hollis. Following his death, fellow Minuteman Preston Garvey took over the squad and led the remaining survivors away from the battle.
Ezra Hollis is only mentioned in Fallout 4.
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