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The End Boss plasma gun is one of Frank Horrigan's two personal weapons.
This unique Enclave weapon is that of a thin-burst plasma gun. An extremely powerful weapon, the end boss plasma gun has a large magazine size, deals out high amounts of damage (even single shots), and is very accurate.
The End Boss plasma gun is nigh impossible to obtain without an inventory editor, but it can be done by having anyone of Granite's team close or inside Horrigan's body to be able to loot it.