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Duke may refer to:
- Duke, a slaver residing in The Pitt in the Fallout 3 add-on The Pitt.
- Duke, a Fiend residing in the South Vegas Ruins in Fallout: New Vegas.
- Duke, a member of the Atom Cats found at the Atom Cats garage in Fallout 4.
- Duke, a member of the Forged in Fallout 4.
- Duke, a dog found at Horizon Flight 1207 in the Fallout 4 add-on Far Harbor.