Cram's presentation is a parody of Spam, down to the same style of packaging and font. In Fallout 3 and Fallout: New Vegas, it was shown to come in a cardboard box, instead of Spam's signature tin can. In Fallout 4, its container was changed to a tin can full of the meat substance with a pull tab to open the container, further likening it to its real-world counterpart.
The name cram itself is likely a reference to the biscuit-like food made by the humans of Lake-town and Dale in The Hobbit and The Lord of the Rings. Unlike Cram, it was made with tightly pressed flour or meal.