The largest single encampment of Legion forces on the western side of the Colorado River, these Arizonian, Legion slavers have a foothold in Nevada, and use this position to bring in troops and supplies from Caesar’s main base on Fortification Hill.
To the south are several buildings with random loot, with the mess hall on the docks in the river. In the center of camp there is a two-story headquarters, with tents just north of this building. Prime legionaries (and later into the game, veteran legionaries) patrol near the headquarters, with several patrols each consisting of a Legion explorer and a Legion mongrel covering all access points. Aurelius of Phoenix can be found in the second story of the headquarters building, outside of his office. Decanus Severus can be found in or next to a tent beside the building.
To the south there is the Cottonwood overlook, where one can easily pick off legionaries with a scoped weapon. On the cliff by Cottonwood overlook is an abandoned truck from San Onofre with copious amounts of nuclear waste. A Lockpick skill of 50 will open the back and release the radioactive contents on the encampment, killing most of the inhabitants. Although the legionaries and everyone else in the area are killed instantly, the actual radiation level in the area is very low and does not prevent anyone from entering the area afterwards.
When approaching the village with Boone, he states that this is a Legion slave camp, that he has been here before, and he will kill everything in it. The way Boone states this could suggest that this is where he tracked down his wife Carla after she was kidnapped by legion slavers.
After every legionary in the camp is killed, Boone will sometimes express disappointment that there were not more of them.
If the Cove has been cleansed with radiation, and one already has (or subsequently obtain) the Mark of Caesar, Cursor Lucullus will still be waiting to ferry them across the river, but he will be wearing a radiation suit.
If chosen to release the radioactive barrels upon Cottonwood Cove without freeing the Weathers family, the family will be killed and the quest Left My Heart will be failed.
If Cursor Lucullus has been killed, it is still possible to travel to the Fort by simply activating the raft at the end of the pier.
Looting inside Cursor Lucullus room will result in negative Karma.
There is a hollowed out rock to the left if one fast travels to Cottonwood Cove. The rock will be marked with the phrase "The sun is killing me" and is located in the path between the two crucifixes.