Convincing Coleridge that Presper deceived them about the New Plague and instead gave him and his men a virus that would eventually kill Coleridge and his NCR guards. This news will get Coleridge to turn on Presper. It also clears the way for the PC to re-target the missiles, if he wants, without opposition.
If the player character is captured, walks in on unexpectedly, or is noticed fiddling with the targeting computer, Presper will initiate dialogue and get the ball rolling. If the player character is "persuasive" enough, they can convince Coleridge that Presper was not honest about giving a lighter strain of the New Plague to Coleridge and his men. Instead, Presper injected Coleridge and his men with a virus that would slowly kill Coleridge and his men, guaranteeing neither he, or his men, would ever enjoy the "brave new world" Presper had planned. This information does not sit well with Coleridge, and he will shoot Presper in the face. He will then set B.O.M.B.-001 to self-destruct and exit via the escape pods, giving the PC three minutes to settle affairs (re-target missiles, dance a jig, get in an escape pod, etc.)