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Caleb may refer to:
- Caleb (Fallout), leader of the Regulators in Fallout.
- Caleb Smith, a stone mason from the Temple of the Union in Fallout 3.
- John Caleb-Bradberton, the inventor of Nuka-Cola and founder of the Nuka-Cola Corporation, mentioned in Fallout 3.
- Caleb McCaffery, a bounty hunter in Fallout: New Vegas
- Caleb (Fallout Extreme), a member of The Cause in Fallout Extreme.
- Real-life person: