The Bishops, headed by the ruthless John Bishop, are a power-hungry family that inhabits the Shark Club casino in 2241. The second most powerful family in New Reno, they seek to end New Reno's mob-based anarchy and bring it into an alliance with NCR and Vault City, working within the NCR's congressional system to legalize prostitution and gambling within the republic.
Whereas most family's missions involve the local intrigues of New Reno's politics, the Bishops are focused more on the politics of the outside world, delivering messages and occasionally poisons to political figures and spies outside New Reno.
John Bishop is a neglectful husband. He is indifferent to the fidelity of his wife, Leslie Anne Bishop, and himself cheats whenever it suits him. It is possible that the Chosen One can have a "relationship" with Mrs. Bishop, who has a child that prefers exploring rather than the mafia and the family. He has also provided little guidance for his daughter, Angela Bishop, who is also promiscuous, and a jet-addict to boot. NCR hired the Bishops as middlemen, who in turn hired the raiders who harass Vault City, in the hopes that it will turn to NCR for protection.
By 2256, the Chosen One's bastard child, Mr. Bishop, by this point only thirteen years old, assumes control over the family, and eventually leads it to victory over the other families in New Reno.
By 2281, Mr. Bishop is still the head of the family. While the Wrights at this point has taken the position as New Reno's leading family, the Bishops remains a force to reckon with, and their influence extends beyond New California, due to Mr. Bishop's eagerness to explore the wastes.