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Betty may refer to:
- Betty, the identity of Stanislaus Braun in the Tranquility Lane simulation in Fallout 3.
- Bumble, a child living in Little Lamplight whose real name is Betty, in Fallout 3.
- Betty (Fallout Tactics), a pre-made player character in Fallout Tactics.
- Betty (Van Buren), a trader and ghoul from the Reservation in Van Buren.
- Hook up Betty and Hank by freeing (acquiring) Jillian, a quest in Van Buren.
- Big Betty, a super mutant member of the Cause and a player character in Fallout Extreme.
- Real-life person: