The daughter of one of the most powerful men in New Reno is definitely not a pampered princess. She learned what it means to be a woman in Reno at a fairly young age and by 2241, her good looks and affinity for tight leather attract men like honey attracts flies. Angela uses this fact to her advantage, reveling in the attention and sexual favors men do for her, becoming something of a legend among New Reno whores.
She is used to having her way and does not take kindly to being turned down, however, in reality, beneath that hardened, lustful exterior lies a sad, broken girl, damaged by Reno and her father's neglection. Drugs, men and abuse of alcohol also took their toll. According to her mother, her hormones are out of control, making her an insanely fertile woman.
If the Chosen One sleeps with her without carrying a condom, the ending for New Reno in which she is the mother of the Chosen One's child triggers, regardless of your further actions in the town (obviously, she needs to survive until the endgame).
Accepting her invitation to go to her room but refusing to sleep with her, results in her crying rape and putting the Chosen One in a world of hurt.
The player has the option of sleeping with her (if male), though unlike her mother, she isn't into women at all. Sleeping with her grants access to her safe (she opens it to get some jet out of it) and contents. However, one should gain access to John Bishop first, lest they face his wrath while attempting to leave (an unavoidable fire fight, unless you hit 0 when Bishop asks you).
Unlike her mother, if the player decides to take down the Bishop crime family, she will go hostile, unless John Bishop is killed in a manner that can't be traced to the Chosen One. Killing John Bishop then escaping New Reno, and returning a day later will cause all dialogue with Angela to be disabled, she will instead say something along the lines of "I know you killed my daddy. I will kill you for this."
If the player plays as a low Intelligence character, Angela will take advantage of this and try and sleep with the player. If the player follows her to her bedroom but refuses to have sex, Angela will start to scream rape, at which point the player has a dialog option of "Shhhh! If you don't be quiet, George won't let me play with th'rabbtiz! Shhhh!" A reference to Lennie Small in Of Mice and Men.
If Angela Bishop is hostile, killing her father will result in her ending all combat with the player. [verified]
If you sleep with Angela Bishop or her mother and while you are stopped by Mr. Bishop when leaving if you tell him "Poor choice of last words." then dialogue will end but he will not be hostile (female characters only). [verified]