Defeat 40 Nuka-World creatures while under the effect of any Nuka-Mix flavor.
- Only those Nuka-Cola mixes the player can craft at Nuka-mixer stations count for this achievement. The new DLC-exclusive Nuka flavors that can be picked up as loot throughout Nuka-World will not work.
- Nuka-Power and Nuka-Sunrise are good choices for anyone intent on unlocking this achievement due to their very long duration once imbibed. Some of their ingredients may be rather uncommon, but the generous amount of time they grant the player to rack up the body count more than makes up for it. Depending on location and situation, one to two bottles of these mixes should suffice for accumulating 40 kills.
- Creatures that count for the achievement are all types of ants, bloodworms, brahmiluffs, cave crickets, gatorclaws, and rad-rats. Reports are inconsistent regarding Nuka-World's local variants of regular Commonwealth creatures like Quantum-infused mirelurks and deathclaws, painted ghouls and ghoulrillas. At least some of the latter, including the Quantum-infused mirelurks, appear to be considered invalid targets.