The .50 MG is a large caliber heavy machine gun and long-range anti-materiel rifle round. It is the largest, most expensive, and heaviest conventional Guns ammunition in the game. The only weapons using it are the anti-materiel rifle and the GRA anti-materiel rifle. It has a weight of 0.25 pounds per round in Hardcore mode, the same weight as a 25mm grenade.
Armor-piercing rounds are designed to pierce through armor plating; for this purpose, they have a greatly strengthened case with a specially hardened and shaped nose. Due to the high muzzle velocity and penetrative properties of the bullet, damage to the target is slightly reduced. These rounds are best used against hardened or armored targets, where penetration is necessitated.
.50 MG, match (hand load)
Match rounds are high-quality rounds manufactured to have identical powder amount, shape, and weight. Match rounds will always be more effective than AP if weapon condition is more than 75%. When the anti-materiel rifle is utilizing this round, it has the lowest spread of any weapon in the game other than the alien blaster and Elijah's jury-rigged Tesla cannon. It requires the Hand Loader perk to craft.
.50 MG, incendiary
Incendiary rounds are designed for igniting targets and are usually used for equipment disposal at extreme ranges. They effectively replace hollow points for .50 MG weapons as they are more effective on unarmored or lightly armored targets due to the added incendiary effect. .50 MG incendiary rounds are affected by the Pyromaniac perk, however due to the pricing these munitions must be used with discretion.
.50 MG, explosive
Only available with the Gun Runners' Arsenal add-on, these rounds are designed to create a secondary explosion upon impact with its target. These are particularly useful against hard armored targets. The explosion created by the round has splash damage, can knock down targets, and is useful for taking out or damaging small groups of enemies.